End-stage renal disease, also called end-stage kidney disease, occurs when chronic kidney disease
— the gradual loss of kidney function — reaches an advanced state. In end-stage renal disease, your kidneys
are no longer able to work as they should to meet your body’s needs.
Your kidneys filter wastes and excess fluids from your blood, which are then excreted in your urine.
When your kidneys lose their filtering capabilities, dangerous levels of fluid, electrolytes and wastes
can build up in your body.

With end-stage renal disease, you need dialysis or a kidney transplant to stay alive. But you may
also choose to forgo dialysis or transplant and opt for conservative care to manage your symptoms
— aiming for the best quality of life possible during your remaining time.